REORIENTING INFORMATION SEARCHING RESEARCH BY APPLYING A SITUATED ABILITIES PERSPECTIVE


The effect of combined chemotherapy with or without potentiation with interferon alpha or tamoxifen for melanoma

BACKGROUND: Metastatic melanoma has shown only limited responsiveness to chemotherapy or immunotherapy.The most commonly used single-agent chemotherapy comes from the nitrosourea group of agents and provides response rates of less than 20%.Several cytotoxic agents have been combined with no dramatic benefit.The incorporation of tamoxifen or interfe

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